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Serological Studies of Seromucoids from Normal Subjects and Patients with Malignant and Non‐Malignant Diseases
Author(s) -
Klatzow David J.,
Vox Gerard H.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02940.x
Subject(s) - orosomucoid , phytohaemagglutinin , medicine , antigen , lymphoma , serology , glycoprotein , immunology , malignant transformation , pathology , gastroenterology , lymphocyte , chemistry , biochemistry , antibody
. During investigations of serum from patients with carcinoma, elevated levels of two proteins were observed. The larger (MW˜44,000) was identified as (α‐acid glycoprotein. The smaller MW˜20,000) has not yet been identified. Further investigation of α‐acid‐glycoprotein‐containing seromucoid showed that many red blood cell and tissue antigens were present, for example, I, i, P 1 Tja (P + P + P k ), H, A, B, Le n , Le bl , M and N. Differences in antigen content between normal serum and serum from carcinoma patients could be demonstrated quantitatively and qualitatively. Seromucoid preparations from patients with Hodgkin's lymphoma inhibited phytohaemagelutinin‐induced lymphocyte transformation more often than seromucoid preparations from normal subjects.