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Human Blood‐Group A ‐ and H ‐Specified Glycosyltransferase Levels in the Sera of Newborn Infants and their Mothers
Author(s) -
Tilley C. A.,
Crookston M. C.,
Crookston J. H.,
Shindman J.,
Schachter H.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02872.x
Subject(s) - fucosyltransferase , transferase , enzyme , glycosyltransferase , blood group antigens , abo blood group system , medicine , immunology , antigen , endocrinology , physiology , biology , andrology , biochemistry
. The level of blood‐group A 1 ‐specified α, 3′‐N‐acetyl‐ D ‐gaIactosaminyl‐transferase in the serum of recently‐delivered women was found to be appreciably lower than the level of this enzyme in the serum of non‐pregnant adults and of newborn infants; a similar but less striking decrease was observed in the levels of the A 2 ‐specified α, 3′‐N‐acetyl‐ D ‐galactosaminyl‐transferase and the H ‐specified α, 2′‐ L ‐fucosyltransferase. Although the red cells of newborn infants are known to have relatively few A and H antigen sites, the serum of neonates was found to have a level of A 1 ‐ and A 2 ‐dependent N‐acetylgalactosaminyltransferases and H ‐dependent fucosyltransferase as high as, if not higher than, the serum of non‐pregnant adults. This finding is compatible with the fact that the haemopoietic tissue contributes only about 20% of the serum transferase level.