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Lymphocyte‐Mediated Antibody‐Dependent Cytolysis: Role in Immune Hemolysis
Author(s) -
Handwerger B. S.,
Kay N. E.,
Douglas S. D.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02482.x
Subject(s) - peripheral blood mononuclear cell , hemolysis , cytolysis , antibody , immunology , cytotoxicity , immune system , lymphocyte , peripheral blood , lysis , medicine , chemistry , in vitro , biochemistry
. Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) antibody.