Premium
A Rapid Automated Latex Screen for Tetanus Toxoid Antibodies
Author(s) -
Booth J. R.,
Nuttall P. A.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02474.x
Subject(s) - toxoid , tetanus , antibody , medicine , clostridium tetani , hemagglutination , immunology , immunoelectrophoresis , virology , vaccination
. This report describes the sensitisation of latex particles and the use of this reagent on the Autotape system to select blood donations containing ≥4 IU/ml of tetanus toxoid antibody. Plasma containing tetanus toxoid antibodies is processed to provide immunoglobulin for passive protection against tetanus. The techniques used for screening include immunoelectro‐phoresis [3], tetanus toxoid sensitised latex particles [5], haemagglutination [1] and automated haemagglutination [6]. The technique used by the Sheffield Regional Transfusion Centre until recently, was immunoelectrophoresis, selecting donors with 4 or more IU/ml. The Autotape system, previously described for brucellosis [4] and syphilis testing [2], provides a system for automated slide testing and a 5‐min tetanus toxoid coated latex test has been developed to select suitable donations for the production of specific immunoglobulin.