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Antisera with la Specificity Selected by Lymphocytes from Patients with Chronic Lymphocytic Leukemia
Author(s) -
Lawler Sylvia D.,
Dewar P. J.,
Mrazek Ivanka,
Jones Elizabeth H.,
Hockley A. B.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02468.x
Subject(s) - chronic lymphocytic leukemia , immunology , lymphocyte , antibody , antiserum , antigen , mixed lymphocyte reaction , leukemia , human leukocyte antigen , biology , microbiology and biotechnology , medicine , t cell , immune system
. Cells from patients with chronic lymphocytic leukaemia (CLL) have been used to screen the sera of pregnant women for antibodies specific for B lymphocytes. The sera have been divided into groups showing la specificity: group I (UK 3) had a positive association with HLA‐B8 and DW 3, and group II (UK 2) with HLA‐B7 and DW2. Groups III, IV and X were independent of each other and of HLA‐A, B and C locus antigens. Certain sera with B‐cell activity showed specific blocking activity in the mixed lymphocyte reaction (MLR), and this activity was dependent on the la specificities and DW specificities of cells used in the MLR. Some sera specifically blocked the responding cells, others the stimulating cells.