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Conceptual Framework Shifts in Immunogenetics
Author(s) -
Hirschfeld Jan
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb04477.x
Subject(s) - abo blood group system , immunogenetics , locus (genetics) , simple (philosophy) , genetics , computational biology , antigen , gene , biology , chemistry , philosophy , epistemology
. The so‐called ' cis AB' blood group is accounted for by proposing that 'normal' anti‐A and anti‐B reagents are cross‐reacting with partially overlapping reaction ranges . Hence, they are labelled anti‐AX and anti‐BX, respectively. Some consequences of a complex‐simple model where 'cis AB' is accordingly produced by a simple (mono‐factorial) antigen X (produced by a simple gene X at the ABO‐locus) are briefly explored.