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Possible Linkage between the Major Histocompatibility Complex and the Immune Response to Factor VIII in Classic Haemophilia
Author(s) -
Frommel D.,
Muller J. Y.,
ProuWartelle Odette,
Allain J. P.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb04473.x
Subject(s) - haemophilia a , haemophilia , immunology , major histocompatibility complex , linkage (software) , immune system , histocompatibility , medicine , genetics , biology , antigen , human leukocyte antigen , gene
. The pattern of HLA segregation was analyzed in 10 sibships of haemophilia A patients, each of which included 1 or 2 haemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.