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The Problem of Platelet Autoantibodies
Author(s) -
MuellerEckhurdt C.,
Mayser Bettina,
Heinrich D.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb04468.x
Subject(s) - autoantibody , thrombocytopenic purpura , platelet , antibody , immunology , globulin , medicine
. To evaluate the applicability of the 14 C‐serotonin release test for the demonstration of platelet autoantibodies, normal test material (sera, plasmas, globulin fractions), HLA‐specific complement‐fixing platelet antibodies and aggregated human γ‐globulin (aγG) were tested in comparison to sera (plasmas, globulin fractions) of 101 thrombocytopenic patients including 46 cases of idiopathic thrombocytopenic purpura. Whereas defined immunological stimuli (HLA antibodies, aγG) were detected with satisfactory precision, platelet autoantibodies could not be demonstrated. Only sera containing HLA antibodies due to previous immunization induced reproducible 14 C‐serotonin release. Results with test material from thrombocytopenic patients were analyzed by 2 times 2 tables and inconsistencies were shown to be caused by methodological variations.