Premium
Anti‐Hepatitis B Immunoglobulin For Clinical Use
Author(s) -
Combridge B. S.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb02252.x
Subject(s) - antibody , antigen , hepatitis b , immunoelectrophoresis , precipitin , immunoglobulin g , surface immunoglobulin , fibrinogen , immunology , counterimmunoelectrophoresis , nephelometry , hepatitis , immunoglobulin m , chemistry , medicine , b cell , biochemistry
. Anti‐hepatitis B immunoglobulin, prepared by a method which involves the initial removal of the fibrinogen fraction, has been reported to lack certain antibodies and fail to detect certain hepatitis B surface antigens when used as a detector reagent in counter‐immunoelectrophoresis. The possibility exists that any passive immunity conferred by the immunoglobulin might not protect against these antigens. Anti‐hepatitis B immunoglobulin prepared from plasma by a modified technique which omitted the precipitation of the fibrinogen fraction reacted against these antigens in gel precipitin tests. It is suggested that such a method is preferable for the production of anti‐hepatitis B surface immunoglobulin.