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Increased Expression in Erythrocytic Ii Antigens in Sickle Cell Disease and Sickle Cell Trait
Author(s) -
Maniatis A.,
Frieman B.,
Bertles J. F.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb02233.x
Subject(s) - sickle cell trait , autoanalyzer , immunology , reactivity (psychology) , sickle cell anemia , cell , red blood cell , antigen , anemia , biology , hemagglutination , disease , medicine , biochemistry , pathology , alternative medicine
. The reactivity of human erythrocytes with anti‐I and anti‐i sera was estimated in 36 normal adults, 18 individuals with sickle cell anemia and 27 individuals with sickle cell trait, by quantitative hemagglutination with a sensitive autoanalyzer system. SS erythrocytes showed significantly increased I and i reactivity when compared to normal erythrocytes. AS erythrocytes also demonstrated some increase in Ii reactivity. No correlation was found between erythrocytic HbF content and i reactivity.