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Distribution of IgG Subclasses in Commercial and Some Experimental γ‐Globulin Preparations 1
Author(s) -
Skvaril F.,
Probst Marianne,
Audran R.,
Steinbuch Marion
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00655.x
Subject(s) - subclass , radioimmunoassay , antiserum , globulin , gamma globulin , distribution (mathematics) , chromatography , chemistry , antibody , immunology , biochemistry , biology , mathematics , mathematical analysis
. The IgG subclass distribution was determined in six commercial and in four experimental human γ‐globulin preparations. The concentrations of IgG subclasses were measured in a modified radioimmunoassay using subclass‐specific antisera. In commercial γ‐globulins, the distribution of the subclasses corresponded roughly lo the distribution in normal human serum. A considerable enrichment of the IgG 4 was found in experimental lots prepared either from the ethanol fraction III or from the rivanol‐precipitable IgG.