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A Comparative Analysis of Methods Suitable for Detection of Platelet Alloantibodies
Author(s) -
Heinrich D.,
Kessler C.,
MuellerEckhardt C.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00654.x
Subject(s) - platelet , antiserum , serotonin , antibody , immunology , autoantibody , antigen , human leukocyte antigen , chemistry , microbiology and biotechnology , medicine , biology , biochemistry , receptor
. Three HLA‐specific antisera were comparatively analyzed by platelet micro‐complement fixation and 14 C‐serotonin uptake and/or 14 C‐serotonin release studies with platelets. In general, there was a good correlation of HLA antibody specificity exhibited in all 3 test systems. Quantitative differences in the response of platelets to HLA antisera were observed and accounted for by differences in antigen density and different types of antibodies involved. Platelet autoantibodies could not be detected by means of 14 C‐serotonin release from platelets in plasma.