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Development of an Intravenous γ‐Globulin with Fc Activities
Author(s) -
Masuho Y.,
Tomibe K.,
Watanabe T.,
Fukumoto Y.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00648.x
Subject(s) - globulin , intravenous use , medicine , gamma globulin , antibody , immunology , anesthesia
. The reconversion of S‐sulfonated antitetanus γ‐globulin (S‐GG) into the original γ‐globulin was studied. S‐sulfonate groups in S‐GG could be converted into disulfide bonds in vitro . The conversion restored the greater part of both complement‐fixing and skin‐sensitizing activities. S‐GG administered intravenously formed interchain disulfide bonds again in vivo , which was accompanied by restoration of the C‐dependent passive hemolytic activity. Intravenous injection of S‐GG did not cause a significant decrease in serum complement level.