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‘VA’, a New Type of Erythrocyte Poly agglutination Characterized by Depressed H Receptors and Associated with Hemolytic Anemia
Author(s) -
Graninger W.,
Poschmann A.,
F'ischer K.,
SchedlGiovani I.,
Hörundner H.,
Klaushofer K.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00630.x
Subject(s) - agglutination (biology) , immunology , hemolytic anemia , red blood cell , hemoglobin , microbiology and biotechnology , chemistry , medicine , biology , biochemistry , antibody
. With help of immunofluorescence, best with anti‐AHp from Helix pomatia , a stippled structure could be demonstrated on the patient's red blood cells. Thus an “A‐like” receptor could be detected on the erythrocyte membrane of this group O patient. The reactive antigen was proved not to be a crypt antigen exposed by the action of neuraminidase. The same stippled fluorescence with anti‐AHp was observed on the red blood cells of a patient suffering from hemolytic anemia induced by influenza A, virus. In this case this virus was shown not to be responsible for polyagglutination. No virus or microorganism could be isolated from the patient's blood. Also by immunofluorescence the weak expression of the H antigen could be demonstrated with an extract of Evonymus europaeus. Electron microscopy of erythrocytes was normal. The neuraminic acid content and the electrophoretic mobility were found to be decreased to a minor degree. No distinct cell populations could be observed.