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‘VA’, a New Type of Erythrocyte Polyagglutination Characterized by Depressed H Receptors and Associated with Hemolytic Anemia
Author(s) -
Serological I.,
Graninger W.,
Rameis H.,
Fischrr K.,
Poschmann A.,
Bird G. W. G.,
Wingham J.,
Neumann E.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00629.x
Subject(s) - anemia , immunology , hemoglobin , red blood cell , receptor , biology , medicine , microbiology and biotechnology , chemistry , endocrinology
. This report describes a case of persistent polyagglutinability restricted to the red blood cells, and associated with hemolylic anemia in a 20‐year‐old male. Anemia was first noted at the age of 5 months and has persisted up to the present time with normal intervals. His red blood cells were weakly agglutinated by almost all adult sera. No autoagglutination was noted and the direct antihuman globulin test was negative. Polyagglutinability of his red blood cells was clearly distinguishable from T, Tn and Tk. No reaction was noted with Dolichos biflorus and peanut extracts. The cells differed from normal erythrocytes in their positive reactions with various snail agglutinins and their weak reaction with a range of anti‐H reagents. There was normal aggregation by Polybrene. MN determinants were normally expressed. The symbol ‘VA’ is proposed for this type of polyagglutination.