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Development of an Intravenous γ‐Globulin with Fc Activities
Author(s) -
Masuho Y.,
Tomibe K.,
Matsuzawa K.,
Ohtsu A.
Publication year - 1977
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1977.tb00622.x
Subject(s) - disulfide bond , chemistry , in vivo , gamma globulin , sulfite , antibody , antigen , sulfonate , biochemistry , globulin , reactivity (psychology) , immunology , medicine , biology , organic chemistry , sodium , pathology , microbiology and biotechnology , alternative medicine
. S‐sulfonated γ‐globulin (S‐GG) was prepared by treating γ‐globulin with sulfite and tetrathionate ions. About four interchain disulfide bonds were selectively cleaved to give S‐sulfonate groups. Although the above treatment strongly suppresses anticomplementary activity and nonspecific skin reactivity, the resulting S‐GG retains high antibody activity. Furthermore, S‐GG was found to maintain satisfactory levels for prolonged periods in vivo. The physicochemical and antigenic analyses of S‐GG suggest that the S‐sulfonation induces structural modification only at restricted sites.