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Linkage Studies between HL‐A and GPT Polymorphisms and Other Genetic Markers 1
Author(s) -
Goedde H. W.,
Stender D.,
Saternus K.S.,
Benkmann HeideG.,
Hiller Ch.,
Stenger O.,
Hoppe H. H.,
Bleschke H.
Publication year - 1976
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1976.tb04835.x
Subject(s) - genetics , linkage (software) , biology , genetic linkage , genetic marker , gene
. The phenotypes of 56 families with 126 children from the Hamburg area as well as gene frequencies and segregation of the genetic markers GPT, AP, ADA, AK, PGM 1 , PGM 3 , 6‐PGD, CHE, C3, Gc, Tf, Hp and Cp were studied. In regard to linkage, the informative families were correlated to the results of HL‐A and GPT typing. The linkage was tested according to the sequential test by Morton (1955). At the recombination fraction Θ = 0.05, independence could be observed for HL‐A/AP, HL‐A/ADA, HL‐A/PGM 1 , HL‐A/C3; HL‐A/Gc, HL‐A/Hp and GPT/AP. In the range of Θ = 0.1, for HL‐A/PGM 1 , HL‐A/Gc and HL‐A/Hp independence was stated. The linkage HL‐A/PGM 3 , reported first by Lamm et al . (1971), could be confirmed. For other gene loci, linkage to the HL‐A or GPT system could not be proved. But the positive lod scores of HL‐A/GPT, HL‐A/AP and GPT/6‐PGD may give indication for linkage.