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Difficulties Encountered in the Large‐Scale Production of Blood‐Grouping Sera from Human Citrated Plasma
Author(s) -
Moghaddam M.,
Goldsmith K. L. G.,
Brazier Diana M.
Publication year - 1976
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1976.tb02835.x
Subject(s) - neutralization , antibody , human plasma , human blood , chemistry , chromatography , ion exchange resin , immunology , medicine , biochemistry , physiology , organic chemistry
. In the production of blood‐grouping serum from human plasma, loss of antibody activity was sometimes noted and was shown to be due to the use of certain batches of cation‐exchange resins used to remove excess calcium ions. These batches of resin were found to be very acid. Complete neutralization of the resin resulted in no further loss of antibody activity.