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Evidence for Cold Immunoglobulin Receptors on Peripheral Blood Lymphocytes in Cryoglobulinaemia
Author(s) -
Secondo V. Rosso Di San
Publication year - 1976
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1976.tb02830.x
Subject(s) - antibody , receptor , immunology , lymphocyte , peripheral blood , population , peripheral , immunoglobulin g , biology , medicine , environmental health
. Leukocyte migration and immunocytoadherence tests have been used to demonstrate cold immunoglobulin receptors on peripheral blood lymphocytes of five patients with mixed idiopathic cryoglobulinaemia IgG‐IgM. Studies of these patients revealed that, contrary to finding with normal subjects, preincubation of lymphocytes at 4°C inhibited their migration and that as this temperature lymphocytes formed rosettes with other lymphocytes from the same subject. Inhibition of migration was, however, not observed when a B lymphocyte‐deprived leukocyte population was used and the rosettes formation was inhibited when pure human immunoglobulins or anti‐immunoglobulin sera were added to the lymphocyte suspension before cold exposure. It is suggested that cold immunoglobulin receptors are present on a proportion of peripheral blood B lymphocytes of cryoglobulinaemic patients.