Premium
An Unusual Rh Phenotype Indicating Heterogeneity of the C w Antigen
Author(s) -
Habibi B.,
André J.,
Fouillade M. T.,
Lopez M.,
Salmon C.
Publication year - 1976
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1976.tb02195.x
Subject(s) - phenotype , antigen , absorption (acoustics) , microbiology and biotechnology , family studies , chemistry , biology , immunology , genetics , gene , materials science , composite material
. A family is reported in which a new C w antigen occurred in two generations. This was recognized by 17 anti‐C w sera, but by none of the 21 anti C sera which were, however, shown to react strongly with common C w + cells. This unusual finding provides evidence that the C w antigen is in fact heterogeneous. On the basis of data obtained from absorption‐elution and coagglutination studies a tentative explanation is attempted: common C w + phenotypes are assumed to be C w (+1+2) and the present phenotype C w (+1–2). Anti‐C w sera should accordingly be anti‐C w1 , whereas anti‐C sera should only react with C w2 .