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A Family with One Child of Phenotype A m Providing Further Evidence for the Existence of the Modifier Genes Yy
Author(s) -
Ducos J.,
Marty Y.,
Ruffie J.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb02794.x
Subject(s) - locus (genetics) , phenotype , gene , genetics , red cell , abo blood group system , biology , heterozygote advantage , allele , gene family , gene expression , medicine
. The study of the Bod. family seems to show the existence of a gene Yy controlling the synthesis of A factor on the red cell. The mother is A 1 and the father A 2 . Four of the five children were studied: one is O, two are A 1 and the fourth is A m . The existence of an O child implies that both parents are heterozygous at locus ABO (A 1 O, A 2 0). Thus, the appearance of an A m subject suggests that, in this specific case, this phenotype is not due to a mutation at ABO locus, but rather to a recessive y gene carried by an independent locus, and which would inhibit the normal synthesis of A on the red cell. This y gene would be heterozygous in each parent (Yy) and homozygous in an A m child; this could explain the inhibition of A factor on the red cell of the subject.