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Glucose‐6‐Phosphate Dehydrogenase Deficiency and Blood Transfusion
Author(s) -
McCurdy P. R.,
Morse E. E.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb02761.x
Subject(s) - glucose 6 phosphate dehydrogenase deficiency , glucosephosphate dehydrogenase deficiency , medicine , glucose 6 phosphate dehydrogenase , blood transfusion , dehydrogenase , red blood cell , pediatrics , biology , enzyme , biochemistry
. Seven White American male blood donors with Italian surnames were found to have red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency among 1,285 with Greek or Italian surnames screened. Five different genetic variants were found: G‐6‐PDs Mediterranean (2), ‘Athens‐like’ (2), San Juan, Columbus and ‘Canton‐like’. Clinical evaluation of 23 patients who received 24 units of G‐6‐PD‐deficient blood (G‐6‐PD A‐) failed to reveal any deleterious effects. Screening of Black donors for G‐6‐PD deficiency is believed unnecessary; further data are needed before a recommendation can be made concerning screening for non‐Black donors.