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Removal of Leucocytes from Whole Blood and Erythrocyte Suspensions By Filtration Through Cotton Wool
Author(s) -
Engelfriet C. P.,
Diepenhorst P.,
Giessen Marijke V. D.,
Riesz Elly
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb02746.x
Subject(s) - antigen , immunology , filtration (mathematics) , red blood cell , granulocyte , immunization , red cell , chemistry , biology , medicine , statistics , mathematics
. Hetero‐immunization experiments in rabbits were performed to evaluate the quantity of leucocyte antigens present in red cell suspensions prepared by the filtration method of D iepenhorst et al. , in which no intact leucocytes could be detected. It was found that the quantity of leucocyte antigens is smallest in blood filtered immediately after taking. More leucocyte‐antigenic material seems to be present in blood that is filtered after storage and in frozen‐thawed red cell suspensions. Evidence was obtained that granulocyte‐specific antigens are more strongly immunogenic in the rabbit than lymphocyte‐specific antigens or antigens common to both cells.