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Over 95% Sensitization against Allogeneic Leukocytes Following Single Massive Blood Transfusion 1
Author(s) -
Gleichmann Helga,
Breininger Josef
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb02743.x
Subject(s) - sensitization , blood transfusion , medicine , immunology , blood preservation , transfusion reaction , blood donor , isoantibodies , antigen , andrology
. The development and persistence of leukoagglutinating and lymphocytotoxic alloantibodies were systematically studied in 54 patients who had received single massive blood transfusions because of open‐heart surgery. Of these patients over 95% were sensitized when tested for both leukoagglutinins and lymphocytotoxins, whereas 74% were found to be immunized when searched for cytotoxic antibodies only. The optimal time for detecting antibodies was 2 weeks after blood transfusions.