Premium
Double Heterozygosity for Hemoglobin Camden ( β 131 Gln→Glu) and Hemoglobin S in an American Negro
Author(s) -
Blackwell R. Quentin,
McCurdy Paul R.,
Liu C.S.,
Wang C.L.,
Huang J. T.H.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb02740.x
Subject(s) - hemoglobin , hemoglobin s , hemoglobin variants , hemoglobin a , hemoglobin c , medicine , disease , sickle cell anemia
. A hemoglobin variant with the slightly fast mobility associated with K hemoglobins was found, together with hemoglobin S, in an apparently healthy 3‐year‐old Negro girl from Washington, D.C. Her father had the same variant, along with hemoglobin A, and her mother had hemoglobins A + S. Respective proportions of hemoglobins K and S in the propositus were 66–34. The K variant now has been found to have the structural change Gln→Glu at position β 131 ( β H9); therefore it apparently is identical to hemoglobin Camden reported in trait form in a Negro subject by Y ates , B ellingham and H uehns (Nature 243 : 467–468, 1973).