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Detection of Antibody to Hepatitis Bs‐Antigen in Patients with Acute and Chronic Hepatitis as Measured by a Modified Procedure of the Radioimmunoassay Ausria I 125®
Author(s) -
Müller R.,
Stephan B.,
Kramer R.,
Deicher H.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb00517.x
Subject(s) - radioimmunoassay , medicine , cirrhosis , viral hepatitis , antibody , hepatitis , immunology , hepatitis b , chronic hepatitis , rheumatoid arthritis , acute hepatitis , gastroenterology , antigen , virus , virology
. A simple modification of the radioimmunoassay Ausria I 125® was employed for detecting anti‐HB s using the inhibition of a constant amount of HB s Ag. Anti‐HB s was demonstrated in up to 82% of follow‐up patients recovering from viral hepatitis B and in 79% of hemophilia patients. The antibody was found in 3.4% of healthy blood donors and in 10% of family contacts of patients with acute HB s Ag‐positive viral hepatitis. The frequency of anti‐HB s in 44 patients with HB s Ag‐negative chronic aggressive hepatitis or cryptogenic liver cirrhosis (23%) did not differ significantly as compared with the occurrence of anti‐HB s in 58 patients with chronic rheumatoid arthritis (16%). These findings give further support to the suggestion that the hepatitis B virus does not contribute to the aetiology of HB s Ag‐negative chronic active hepatitis.