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Loss of Rh Antigen Activity Following the Action of Phospholipase A 2 on Red Cell Stroma
Author(s) -
HughesJones N. C.,
Green Elizabeth J.,
Hunt Valerie A. M.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb00493.x
Subject(s) - stroma , phospholipase , red cell , antigen , phospholipase a , chemistry , phospholipase c , red blood cell , phospholipase a2 , microbiology and biotechnology , cell , biochemistry , enzyme , biology , immunology , medicine , immunohistochemistry
. The degradation of red cell stroma phospholipids by phospholipase A 2 is accompanied by a concomitant fall in the activity of the Rh antigens, c, D and e. The action of phospholipase C on stroma also brings about a fall in D antigen activity. Anti‐D bound to the red cells protects the D antigen from inactivation by phospholipase A 2 .