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A Clinical Evaluation of Citrate‐Phosphate‐Dextrose‐Adenine Blood
Author(s) -
Kreuger Anders,
Åkerblom Olof,
Högman Claes F.
Publication year - 1975
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1975.tb00483.x
Subject(s) - red blood cell , red cell , whole blood , blood transfusion , blood preservation , medicine , chemistry , andrology , surgery
. (1) Blood was stored in polyvinyl‐chloride bags containing citrate‐phosphate‐dextrose (CPD) with adenine in a final concentration of 0.25 mM. (2) Red cell ATP was well maintained (>70% of original) for 4 weeks in whole blood as well as in red cell concentrate (PCV 85 ± 2%). After 5 weeks the ATP level was about 70% in whole blood and about 40% in red cell concentrate. (3) Red cell 2,3‐diphosphoglycerate (DPG) was about 60% of the original after 2 weeks and about 30% after 3 weeks of storage when stored both as whole blood and as red cell concentrate. (4) The red cell 24‐hour post‐transfusion viability was about 80% after 4 weeks of storage both as whole blood and as red cell concentrate. After 5 weeks of storage the 24‐hour viability was 78.7 ± 3.5% in whole blood and 76.5 ± 6.7% in red cell concentrate. (5) 820 patients received 3,238 units of CPD‐adenine blood, and 761 patients serving as controls received 2,807 units of acid‐citrate‐dextrose (ACD) blood. The frequency of transfusion reactions was 3.5% for patients receiving CPD‐adenine blood and 4.1% for the control group. (6) The maximum storage time was set at 5 weeks for the CPD‐adenine blood and 3 weeks for the ACD blood. The longer preservation time decreased out‐dating by at least 50%.