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Le x , the Spurned Antigen of the Lewis Blood Group System 1
Author(s) -
Arcilla Minerva B.,
Sturgeon Phillip
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02717.x
Subject(s) - saliva , microbiology and biotechnology , titer , antigen , cord blood , chemistry , genotype , antibody , gene , biology , immunology , biochemistry
. Studies are reported on the Le x antigen‐antibody system which serologically distinguish it from Le a and Le b . The essential characteristic of anti‐Le x is that it divides cord cells, which typically are Le(a–b–) in two classes, approximately 90% Le(a–b–x+) and 10% Le(a–b–x–). All infants and adults, regardless of secretor status, whose genotype includes the Le gene are Le x ‐positive and all type le/le subjects are Le x ‐negative. Le x ‐inhibiting activity is found in saliva, serum and amniotic fluid of Lewis‐positive individuals. Wide ranges in the ratios of the titers of Le a /Le x , Le b /Le x , and Le c /Le x substances indicate that Le x does not correspond with any of the three other Lewis specificities. It is postulated that type II precursor substance is substrate for the action of the Le gene product resulting in Le x substance.