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Complement‐Mediated Changes in Morphology of Hepatitis B Antigen‐Antibody Complexes 1
Author(s) -
Hirschman Shalom Z.,
Kochwa Shaul,
Rosenfield Richard,
Schwartz Jerome
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02690.x
Subject(s) - complement (music) , antigen , antibody , complement system , morphology (biology) , chemistry , hepatitis , immunology , biophysics , biology , biochemistry , phenotype , genetics , complementation , gene
. The size distribution of particles of purified hepatitis B antigen (HB Ag) was altered by the action of complement. Prior to exposure to complement 94% of round particles of HB Ag were in a size distribution of 10–18 nm with a modal diameter of 15 nm. The modal diameter of particles treated with complement increased to 19 nm and particles larger than 30 nm were prominent. This effect on the morphology of HB Ag may be due to an enzymatic action of complement.