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Presence of Chronic Lymphoid Leukaemia Associated Antigen in Other Malignant Haematological Diseases
Author(s) -
Phan Do Trung,
Petrányi Gy. G.,
Hollán Susan R.
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02679.x
Subject(s) - medicine , antiserum , lymphoma , immunology , antigen , bone marrow , lymphatic system , lymphocyte , pathology
. 13 rabbits were immunized each with peripheral blood lymphocytes from one of 13 different patients with chronic lymphoid leukaemia. The antisera were absorbed with human erythrocytes and peripheral blood lymphocytes from normal donors. Absorbed specific antiserum was applied for detecting the presence of chronic lymphoid leukaemia associated antigen on the lymphocytes from 60 patients with chronic lymphoid leukaemia, 8 patients with acute lymphoid leukaemia, 10 with lymphosarcoma, 12 with reticulosarcoma, 11 with Hodgkin's disease, 7 with multiple myeloma and 4 with Waldenström's macroglobulinaemia, further on the lymphocytes from the appendices of 5 healthy donors, on bone marrow lymphocytes of one healthy subject, on the thymocytes of 4 human embryos, and on lymphocytes isolated from the peripheral blood of 157 normal donors. The absorbed antisera were highly reactive with cells from 60/60 patients with chronic lymphoid leukaemia, 5/5 patients with acute lymphoid leukaemia, and 7/10 patients with lymphosarcoma. The lymphocytes of three acute lymphoid leukaemia patients in the phase of remission failed to react with the absorbed specific antiserum. The absorbed antisera failed to react by cytotoxicity against lymphocytes from other types of malignant lymphoma, and against those from patients with acute and chronic myeloid leukaemia, and against T and B lymphocytes from normal donors.