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Recovery of Hepatitis B Antibody from Human Plasma Products Separated by a Modified Cohn Fractionation
Author(s) -
Berg J. V. Rebekka,
Berntsen K. O.,
Björling H.,
Holmström Björn,
Vyas G. N.
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02423.x
Subject(s) - antibody , fractionation , hepatitis b immune globulin , immunodiffusion , gamma globulin , antigen , hemagglutination , radial immunodiffusion , hepatitis , globulin , hepatitis b , immunology , immune system , immune adherence , chemistry , virology , chromatography , medicine , hepatitis b virus , virus , hbsag
. Hepatitis B immune globulin has been prepared for clinical trials in Sweden. The relative amount of antibodies to the hepatitis B antigen recovered in the respective fractionation steps was evaluated by hemagglutination, immunoelectro‐osmophoresis and radial immunodiffusion. About one third of the antibody amount present in the original plasma pool was recovered in fraction II. Hepatitis B antigen was neither demonstrated in the various fractionation steps nor in the final immune globulin preparation.