Premium
Sa 1, a Possible New HL‐A Specificity Found in the Japanese Population
Author(s) -
Nakayama E.,
Itakura K.,
Yakura H.,
Aizawa M.,
Kuroda M.,
Hanada K.
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02401.x
Subject(s) - histocompatibility , allele , human leukocyte antigen , antigen , antibody , immunology , polymorphism (computer science) , major histocompatibility complex , allele frequency , genetics , population , biology , immunogenetics , gene , medicine , environmental health
. A possibly new HL‐A specificity, associated with W22, was found in the Japanese. Population and family studies indicate that the gene Sa 1 (frequency 0.0771) behaves as a ‘new’ allele at FOUR sublocus. A case of crossing over between the LA and FOUR loci of the HL‐A system was also described. The HL‐A system of leukocyte antigens is the major histocompatibility system in man, and exhibits a remarkable degree of allelic polymorphism [6, 8, 9]. The 5th Histocompatibility Workshop was devoted to an anthropological survey of HL‐A throughout the world, and 54 different populations were studied by the participating laboratories [7]. These studies have shown that each ethnic group possesses its own characteristic HL‐A profile. Also remarkable is the higher frequency of the unknown HL‐A antigens of the FOUR series in Orientals [1, 10, 12, 13]. Screening for antibodies with cells of Japanese, therefore, will offer a chance of detecting sera against unknown factors. The present study reports the presence of antibody against a possibly new HL‐A specificity, Sa 1, associated with W22, found in the sera of some Japanese multiparous women. In addition, a case of crossing over between the LA and FOUR loci of the HL‐A system is presented.