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The Characterisation and Stability during Storage of Human Immunoglobulin Prepared for Clinical Use
Author(s) -
Mackay Margaret,
Vallet L.,
Combridge B. S.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb04820.x
Subject(s) - chromatography , isoelectric focusing , antibody , chemistry , fractionation , immunoglobulin g , biochemistry , immunology , medicine , enzyme
. The effects on human immunoglobulin of preparation by solvent fractionation and of storage under different conditions are described. Samples were examined by ultracentrifugation, electrophoresis and electrofocusing in polyacrylaniide gel, by gel chromatography and complement fixation. Changes under extreme or prolonged storage conditions were apparent in anticomplement activity before they were detected by other techniques. There was no evidence of any major change in clinical immunoglobulin during storage for 4 years at 4°C.