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Australia Antibody Production elicited by Heat‐Treated Human Plasma Protein Solution
Author(s) -
Mori Y.,
Momose M.,
Nakano Y.,
Ata S.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb04367.x
Subject(s) - antibody , antigenicity , antigen , infectivity , titer , immunology , medicine , antibody titer , virology , chemistry , virus
. Nine patients given heat‐treated (60 °C, for 10 h) human plasma protein solution (Plasmanate, PPS) developed antibody against Australia antigen (Au antibody), while none of the patients manifested either Australia antigen (Au antigen) or clinical hepatitis. It is conceivable that Au antigen present in PPS was deprived of its infectivity but retained its antigenicity. Au antibody developed early in 7 of 9 patients after the first infusion. Of those, 4 patients showed high Au antibody titers of 8–32. Au antibody persisted from 4 to 82 days in 8 patients and for 74 weeks in the remaining one.