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An Inherited Blood Group A Variant in the Finnish Population
Author(s) -
Mohn J. F.,
Cunningham R. K.,
Pirkola Anna,
Furuhjelm U.,
Nevanlinna H. R.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb04365.x
Subject(s) - agglutination (biology) , antibody , saliva , phenotype , immune system , direct agglutination test , population , biology , group a , immunology , microbiology and biotechnology , serology , genetics , medicine , gene , biochemistry , environmental health
. A variant of blood group A, provisionally designated A inn , that occurs in an overall frequency of approximately 1 in 6,000 in Finnish blood donors is described. Agglutination involving a very small number of erythrocytes was observable only microscopically, even with the most powerful immune anti‐A sera. However, potent anti‐A antibody eluates were produced from cells sensitized with both natural and immune anti‐A or anti‐A + B sera. Anti‐A 1 agglutinins were demonstrated in the sera of all cases, and the saliva of secretors contained H but no A substances. Comparative examinations and previously published descriptions of other established variants clearly indicated that this was not identical with the A bantu , A m , A x , or A e1 phenotypes. These properties are similar to those reported for group A end , except for enzyme pretreatment effecting macroscopically visible agglutination of A ***inn cells.