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A Comparative Study of Antiglobulin Antibodies and Residual Anti‐D Between Recipients of Intramuscular Anti‐D Immunoglobulin and Intravenous Plasma Anti‐D 1
Author(s) -
Vos G. H.,
Shapiro M.,
Burgess B. J.,
Vos D.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb03854.x
Subject(s) - antibody , immunology , immunoglobulin g , medicine , globulin , intramuscular injection , chemistry
. The incidence of ‘specific’ and ‘non‐specific’ antiglobulin antibodies was determined among 648 multiparous females, 213 recipients of intramuscular anti‐D immunoglobulin and 221 recipients of intravenous plasma anti‐D. Results obtained six months after the administration of anti‐D showed that the formation of ‘specific’ anti‐Gm or anti‐Inv was no greater in recipients of anti‐D immunoglobulin or plasma anti‐D than in the controls. The incidence of ‘non‐specific’ antiglobulins increased from an expected 5% among recipients of intravenous plasma anti‐D to almost 25% in mothers given intramuscular anti‐D immunoglobulin. It is suggested that the raised ‘non‐specific’ antiglobulins may be provoked by a residue of aggregated γ‐globulin components which is known to be present in preparations of Cohn fraction II. Six months after the passive administration of Rh antibodies residual anti‐D activity was more often observed in recipients of intramuscular anti‐D immunoglobulin than in recipients of plasma anti‐D.