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Selective Serum IgA Deficiency
Author(s) -
Frommel D.,
Moullec J.,
Lambin P.,
Fine J. M.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb03545.x
Subject(s) - incidence (geometry) , selective iga deficiency , consanguinity , population , volunteer , medicine , double diffusion , immunology , iga deficiency , demography , antibody , pediatrics , biology , environmental health , virology , agronomy , physics , sociology , optics
. The frequency of isolated IgA deficiency was determined in a healthy population of 15,200 volunteer French blood donors. The screening was performed either by inhibition of passive haemagglutination or by double diffusion analysis in gel. The results obtained with the two methods were concordant. In the Parisian population, the incidence of selective IgA deficiency characterized by a serum level below 0.5 IU, was found to be 1/3,040. This index is lower than that reported by most other investigators: 1/300‐1/3,000. These discrepancies depend on the type of population chosen for inquiry. In open and ethnically mixed populations, the incidence of IgA deficiency is lower than in more sedentary, rural, populations in which the probability of distant consanguinity is increased.