Premium
Hepatitis: Intrahepatic Expression of Au Antigen and Immune Complexes in Liver Tissue
Author(s) -
Kater L.,
Gorp L. H. M.,
BorstEilers E.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb03509.x
Subject(s) - antigen , antibody , immune system , immunology , hepatitis , viral hepatitis , pathogenesis , virology , immune complex , medicine
. Seventy patients with various liver disorders were studies for the presence of Au antigen in their blood, as well as for the presence of Au antigen, immunoglobulins and complement in their liver. In 18 patients, we could demonstrate Au antigen in the serum; in all of these, Au antigen was also found in the liver. In both Au‐positive and Aunegative viral hepatitis cases, we observed granular deposition of IgG and complement in the liver along vessel walls and sinusoids. These findings suggest that immune complexes are involved in the pathogenesis of viral hepatitis.