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Persistent Mixed Field Polyagglutinability: An Immunofluorescence Study in Genetically Abnormal Red Cells 1
Author(s) -
Poschmann A.,
Fischer K.,
Reuther K.,
Myllylä G.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb03491.x
Subject(s) - immunofluorescence , microbiology and biotechnology , biology , snail , transplantation , indirect immunofluorescence , receptor , albumin , chemistry , immunology , antibody , biochemistry , medicine , ecology
. Immunofluorescence studies of erythrocytes from Mr. O. S. (group O blood donor) showing persistent mixed field polyagglutinability are reported. In addition to human and animal sera, various extracts from plant seeds (anti‐T Ah , anti‐BH Ee ) and albumin glands of snails (anti‐A HP , anti‐A CN , anti‐A CH ) were applied. There was normal release of cryptantigens following RDE treatment of OS cells. Rh receptor D was normal. In contrast, the strong reaction with anti‐A reagents from snails and Dolichos biflorus (anti‐ADb) was abnormal. The presence of one or several components of A receptor substance is discussed. 50.75% of 6,353 OS cells were immunofluorescent positive with application of snail anti‐A agglutinins. Transplantation chimerism appears unlikely. A mutation during early embryonal differentiation is suspected.