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Presence and Origin of Human IgG Subclass Proteins in Newborns
Author(s) -
Mellbye O. J.,
Natvig J. B.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb02632.x
Subject(s) - subclass , in utero , fetus , immunology , cord , hemagglutination , antibody , cord blood , biology , andrology , medicine , pregnancy , genetics , surgery
. Using haemagglutination inhibition tests specific for Gm types connected with IgG1, IgG2 and IgG3, and similar tests specific for Fc IgG4, the four subclasses of IgG were present in all of 29 human cord sera. The inhibition titres were similar to those in maternal sera. The Gm phenotype of a cord serum was always identical to that in the corresponding maternal serum. Some cord sera in addition contained small amounts of IgG with Gm types differing from that of the mother, these were probably produced by the fetus in utero. In sera obtained from the same children at 9 months of age, cases were found where Gm types, present at birth, had disappeared. The results indicate that both IgG1, IgG2 and IgG3 are transferred from mother to fetus before birth, and they are consistent with a similar transport also for IgG4.