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A New Antibody, Anti‐K12, Associated with the Kell Blood Group System 1
Author(s) -
Marsh W. L.,
Stroup Marjory,
Macilroy Mija,
øyen Ragnhild,
Reid Marion E.,
Heistø H.
Publication year - 1973
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1973.tb02631.x
Subject(s) - phenotype , antibody , antigen , red blood cell , immunology , blood group antigens , biology , microbiology and biotechnology , gene , genetics
. A new antibody, named anti‐K12, reacts with a high‐frequency red‐cell antigen associated with the Kell blood groups. Two examples have been found, both in people having the phenotype K‐k+, Kp(a–b +), Js(a–b +). Anti‐K12 reacted with all of 1,000 random blood samples, less strongly with some Kp(a + b–) samples, weakly with red cells of the McLeod phenotype and not at all with K o red cells. It reacted weakly against red cells from children with chronic granulomatous disease with weak Kell antigens. While the data establish a phenotypic association between the K12 antigen and the Kell system, there is no evidence to show whether K12 is an inherited character, and, if so, whether the controlling gene is part of the Kell complex.