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The Effect of Methylene Blue Addition to Whole Blood during Prolonged Storage
Author(s) -
Kocholaty W. F.,
Dawson R. B.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb05197.x
Subject(s) - methylene blue , glutathione , chemistry , hemoglobin , glutathione reductase , adenosine triphosphate , biochemistry , medicine , enzyme , glutathione peroxidase , photocatalysis , catalysis
. Addition of methylene blue (MB) in concentrations of 10 –3 , 10 –4 and 10 –5 m to CPD blood resulted in lowered levels of glutathione and glutathione reductase. The levels of adenosine triphosphate were not affected by the addition of MB. However, the 2,3‐diphosphoglycerate levels remained higher than the control values after 21–42 days of storage at all MB concentrations used. Hemoglobin function was better maintained by the two lower concentrations of MB during most of the storage period. The highest concentration had an adverse effect, lowering the p 50 below the control level in CPD.