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Protection by Various Catatoxic Steroids and Estradiol against the Fatal Hemorrhagic Syndrome Produced by Bishydroxycoumarin in the Rat
Author(s) -
Selye H.,
Szabo S.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb05196.x
Subject(s) - oxandrolone , spironolactone , pregnenolone , medicine , antidote , hormone , steroid , toxicity , growth hormone , heart failure
. Various catatoxic steroids (particularly spironolactone and oxandrolone) offer protection against the fatal hemorrhagic syndrome induced by bishydroxycoumarin overdosage in the rat. However, estradiol is even more efficacious in this respect, both in the presence and the absence of the ovaries. Unexpectedly, pregnenolone‐16α‐carbonitrile (PCN), the most active catatoxic steroid, as judged by its ability to detoxify other substrates, offers no protection against bishydroxycoumarin.