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Blood Viscosity, Erythrocyte Aggregation, and Recovery from an Experimental Hemorrhagic Shock
Author(s) -
LundsgaardHansen P.,
Marti B.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb05118.x
Subject(s) - dextran , hematocrit , rheology , dextran 70 , gelatin , chemistry , blood viscosity , shock (circulatory) , erythrocyte aggregation , hemorrhagic shock , plasma volume , blood volume , viscosity , chromatography , medicine , anesthesia , biochemistry , materials science , composite material
. Following a standardized hemorrhagic shock, a total of 70 rabbits were infused with washed autologous erythrocytes suspended in different dextran and gelatin preparations with varying rheological properties, the effects of which on metabolic recovery from the shock state were studied. The only significant finding was an inhibited recovery of the arterial pH 3 and 6 h after infusion of 0.64 g/kg dextran 500,000, which accelerated the erythrocyte sedimentation rate to 131 mm/60 min and simultaneously increased whole blood viscosity to a value equalling a hematocrit of 78% in an otherwise normal animal. Two conclusions are drawn: first, the theoretically unfavorable rheological properties of commercially available plasma substitutes based on dextran (increased plasma viscosity) and on gelatin (accelerated ESR) are insignificant compared to their volume replacement effects; second, the rheological perturbations induced in other studies with 1.0 g/kg dextran 1,000,000 are beyond the physiologically and clinically relevant range.