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The Relationship of the H Specificity to the ABO Blood Groups
Author(s) -
Wiener A. S.,
Socha W. W.,
Gordon E. B.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb05116.x
Subject(s) - abo blood group system , steric effects , serology , reactivity (psychology) , lectin , chemistry , biology , biochemistry , immunology , antibody , stereochemistry , medicine , pathology , alternative medicine
. Racial differences are demonstrated in the reactions of human red cells of groups A 1 and B with anti‐H lectin. These and other findings argue against the concept that H is a precursor of A and B. A more likely hypothesis appears to be that there are individual, racial and species differences in the precursor substance which provides the chemical skeletons to which are added the determinant sugar groups responsible for specificities H, A and B. The differences in reactivity with anti‐H are ascribed to differences in the proximity between the various determinant groups with resulting steric interference with the serologic reactions.