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Lymphocyte Antigens in Patients with Down's Syndrome
Author(s) -
Boxer L. A.,
Yokoyama M.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb04643.x
Subject(s) - antigenicity , antigen , immunology , typing , lymphocyte , cellular immunity , medicine , haplotype , down syndrome , biology , genetics , gene , genotype
Summary The present study was designated to test whether surface antigenicity would be reduced in patients with Down's syndrome as a reflection of diminished protein synthesis in response to stimulators of cellular immunity. Leukocyte typing was carried out on lymphocytes from 23 Caucasian children and 13 Japanese children, all with Down's syndrome. It was found that the lymphocytes from patients with Down's syndrome reacted less frequently than the control group in the microcytotoxicity test. Furthermore, in 6 families available for full study, patients with Down's syndrome showed marked deletions of the expected HL‐A haplotype. The findings of diminished antigen reactivity may be related to the phenomenon of triploidy.