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Changes in Erythrocyte Membranes during Cold Storage of Whole Blood
Author(s) -
Moore G.L.,
Antonoff R.S.,
Rau D.C.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb04635.x
Subject(s) - membrane , proteolysis , erythrocyte membrane , red blood cell , chemistry , flexibility (engineering) , blood preservation , biophysics , biochemistry , chromatography , biology , physiology , enzyme , statistics , mathematics
. Various assays and physicochemical methods were used to observe changes taking place in membrane proteins from erythrocytes that had been stored up to 42 days at 4°C. Red cell membranes were found to decrease in hydrophobicity, flexibility, and sulfhydryl content on storage. These changes are not due to proteolysis, but related to an unresolved change in the structural characteristics of the lipoproteins comprising the ‘membrane superstructure’.