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Two Siblings with Rh null Disease
Author(s) -
Seidl S.,
Spielmann W.,
Martin H.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb04000.x
Subject(s) - serology , medicine , splenectomy , phenotype , immunology , genetics , biology , gene , antibody , spleen
. Two siblings with the rare phenotype Rh null are described; the parents are related to each other. Serologic investigation of the family gives indirect support for the action of an amorphous gene. As demonstrated in the propositus, the splenectomy resulted in health improvement. Titration tests in 1,803 unrelated blood donors revealed 4 heterozygous — types. On the basis of this calculation one can assume one Rh null patient among 6 million inhabitants.