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The IgG Subclass Distribution in 659 Myeloma Sera
Author(s) -
Skvaril F.,
Morell A.,
Barandun S.
Publication year - 1972
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1972.tb03848.x
Subject(s) - subclass , multiple myeloma , myeloma protein , distribution (mathematics) , antiserum , antibody , immunoglobulin light chain , immunoglobulin g , microbiology and biotechnology , chemistry , immunology , medicine , biology , mathematics , mathematical analysis
. The IgG subclass of 659 IgG myeloma proteins was determined with subclass‐specific antisera in agar precipitation technique. The following distribution was found: IgG1, 80%; IgG2, 10%; IgG3, 6.4%; IgG4, 3.6%. In addition, the light chain distribution among myeloma proteins of the subclasses was studied. The K/L ratio of the IgG1 proteins was 1.7; IgG2, 2.05; IgG3, 2.2; and IgG4, 3.0. These ratios did not differ significantly. In 9 sera with IgG double M‐components, the combination IgG1‐IgG4 was found to be predominant.